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Villacabras ravine, Villaconejos, Community of Madrid, Spain

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Very close to Aranjuez, Chinchón and WARNER park

The distance between Madrid and Villaconejos is 39 km. The road distance is Receive the daily newsletter in your email for free Click here. You are receiving this pop-up because this is the first time you are visiting our site. If you keep getting this message, please enable cookies in your browser. Based on your current location, we selected the Asia edition of FreshPlaza.

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San Esteban de Gormaz is also notable, one of the largest towns in Soria with a rich heritage, including its castle, the largest in Europe. Burgos welcomes us with plenty to enjoy, delighting the eye with towns like Santo Domingo de Silos and its beautiful monastery and a long list of other interesting sites, beginning with the surrounding countryside and the spectacular sight of the town as you approach on the hilltop path.

Mecerreyes is a picturesque, welcoming village which treats pilgrims very well, offering a hostel of the finest quality in a restored building in the style of a traditional farmhouse.

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F83 del GJB2 mutation in a family with prelingual sensorineural deafness.

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Non-syndromic hearing loss is one of the most common hereditary determined diseases in human, and the disease is a genetically heterogeneous disorder. Mutations in the GJB2 gene, encoding connexin 26 Cx26 , are a major cause of non-syndromic recessive hearing impairment in many countries and are largely dependent on ethnic groups. Due to the high frequency of the c. Here we present on the clinical and molecular genetic evaluation of a family suffering from prelingual, sensorineural, non-syndromic deafness. A novel c. F83 del GJB2 mutation was detected in compound heterozygosity with the c.

We conclude that compound heterozygosity of the novel c. F83 del and the c. All rights reserved. Reproductive biology of the Del Norte salamander Plethodon elongatus. We examined seasonal reproductive patterns of the Del Norte Salamander, Plethodon elongatus, in mixed conifer and hardwood forests of northwestern California and southwestern Oregon.

Seasonal size differences in reproductive structures suggested that maximum spermatogenic activity occurred during the late summer, with spermatozoa transfer to the Should the Secure Rural Schools Act be reauthorized, the An analysis of academic activities of college faculty at the eight campuses of Chile's Universidad Tecnica del Estado was conducted. Activities were grouped into seven categories: direct teaching, indirect teaching, research, community services, faculty development, academic administration, and other activities.

Following the narrative…. Our results led us to conclude that the pre-atmospheric radius might have been approximately 2 m. Comparisons with other big bodies are also presented.

Additional information is contained in the original extended abstract. The students should also be familiar with basic concepts in English such as math…. Design, aerodynamics and autonomy of the Del Fly.

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One of the major challenges in robotics is to develop a fly-like robot that can autonomously fly around in unknown environments. In this paper, we discuss the current state of the Del Fly project, in which we follow a top-down approach to ever smaller and more autonomous ornithopters. The presented findings concerning the design, aerodynamics and autonomy of the Del Fly illustrate some of the properties of the top-down approach, which allows the identification and resolution of issues that also play a role at smaller scales. An experimental aerodynamic investigation revealed that this could be associated with an improved stiffness of the wing, while further providing evidence of the vortex development during the flap cycle.

The presented experiments resulted in an improvement in the generated lift, allowing the inclusion of a yaw rate gyro, pressure sensor and microcontroller onboard the Del Fly. The autonomy of the Del Fly is expanded by achieving 1 an improved turning logic to obtain better vision-based obstacle avoidance performance in environments with varying texture and 2 successful onboard height control based on the pressure sensor. Analisis del contenido curricular de los Documentos Normativos del Programa de Ciencias en el area de biologia para la escuela superior del sistema de educacion publica de Puerto Rico: Esta investigacion de naturaleza cualitativa se ocupo de realizar un analisis de contenido documental de los Documentos Normativos del Programa de Ciencias en el area de biologia de la escuela superior del sistema de educacion publica de Puerto Rico del periodo El analisis sugiere que no hubo cambios sustanciales en los significados de los Componentes Estructurales.

Los documentos estudiados muestran mayormente caracteristicas similares, aunque los documentos mas recientes eran mas descriptivos, explicativos y especificos. This work is an extened summary of the autor's PhD thesis. At first, students teachers' undestanding of astronomical concepts related to Sun-Earth system have been analysed. Taking into account the results of the previous analysis and using a socio-constructivist approach a teaching sequence has been designed.

This sequence has been tested with different groups of students teachers showing an improvement in their undestanding of elementary astronomical concepts. El trabajo que presentamos es un resumen extenso de la tesis doctoral del autor. New records of fishes at Isla del Coco, Costa Rica.

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Isla del Coco lies at 5 degrees 32'N latitude, 87 degrees 04'W longitude and is the sole peak of the Cocos Ridge exposed above sea level. This isolated island formed approximately 2 million years ago.

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It rises m above the surface of the sea and covers 46 km2 Castillo et aI. The area of the park was increased to include the adjacent waters 5 km offshore in and 25 km offshore in It offers high-school teachers a tool for teaching Astronomy to 10 to 17 year-old students. Different programs, experiments, and audiovisual presentations have been prepared by a team formed both by professional astronomers and teachers, and are offered in a format chosen to suit each particular age and curriculum group.

Special sessions have been designed for students with special needs for example blind or autistic children in close contact with the pedagogical teams responsible for their education. Evidenze scientifiche]. La terapia farmacologica nei pazienti con disturbo da uso di alcol riveste un ruolo centrale nel progetto terapeutico, altamente contestualizzato in un approccio multidisciplinare.

Nuovi approcci sperimentali stanno cercando di ampliare tale gamma attraverso l'utilizzo di farmaci off-label. Fondamentale risulta il follow-up per valutare la ritenzione in trattamento e il monitoraggio degli outcome alcologici. Carbon decomposition dynamics have been studied in a variety of ecosystems and its variation can mostly be explained in terms of environmental variables e.

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However, carbon dynamics in arid, water limited regions have shown to be very different and are still largely unknown. Several studies have indicated the importance of photodegradation, the direct breakdown of organic matter by sunlight, in these arid regions. The FTIR was connected to 2 different flux measurement systems: a Flux Gradient system and 2 flux chambers, providing a continuous data set of gas concentrations and biosphere-atmosphere gas fluxes at different heights and scales.

Field measurements showed photodegradation induced carbon fluxes. A clear diurnal pattern in respiratory del 13CO2 was found, suggesting either different dominant respiratory processes between day and night or the effect of diffusive fractionation. Poor visibility is a subject of growing public concern throughout the U. S, and an active area of research. Its societal impacts on air quality, aviation transport and traffic are significant.

Aerosols play a fundamental role in the attenuation of solar radiation, and also affect visibility. The scattering and extinction coefficients of aerosol particles in the Paso del Norte Region have been calculated using the T- matrix model in conjunction with a laser particle counter. Inter-comparison of the model's results of the scattering and absorption coefficients against the corresponding data from a Photoacustic extinctiometer instrument which measures in-situ absorption and scattering coefficients of aerosol particles shows excellent agreement.

In addition, the volume-weighted method is used to determine the composite index of refraction which is representative of the aerosols for the Paso del Norte Region to obtain information of the type of aerosol particles present in the Region. The Single Scattering Albedo has also been retrieved using this methodology to obtain further insight into the type of aerosols present on a given day. Finally, the Koschmieder equation has been used to calculate the visual range or visibility, and was correlated with the PM2.

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Our methodology will allow a better understanding of the size and type of aerosol particles that are most detrimental to the visibility for the Paso Del Norte Region. A differential diagnostic role for plasma Del -1 was proposed for early breast cancer EBC in our previous study.

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We examined tumoral Del -1 expression and analyzed its prognostic impact among patients with EBC. Del -1 mRNA expression was assessed in breast epithelial and cancer cells. Meanwhile, the tumoral expression of Del -1 was determined based on tissue microarrays and immunohistochemistry results from patients.

Tumoral expression of Del -1 was also significantly associated with a negative expression of estrogen receptor or progesterone receptor, and low expression of Ki, particularly in the case of triple-negative breast cancer TNBC p Del -1 expression and an aggressive histological grade, nuclear mitosis, and polymorphism, suggesting a possible role in tumor progression.

In the survival analysis, a worse distant disease-free survival trend was noted for the group overexpressing Del While all the investigated breast cancer cell lines exhibited Del -1 expression, the expression rate and intensity were specifically prominent in TNBC. In addition, based on its relationship to an unfavorable histology and worse survival trend, Del -1 could act as a molecular target in TNBC patients.

The study consisted of identifying species in 40 plots of m2 each, measuring the diameter at Scientists from many parts of the world are combining ground research with NASA's AirSAR technology to improve and expand on the quality of research they are able to conduct.

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AirSAR will provide a baseline model and unprecedented mapping of the region. This data will make it possible to determine whether the warming trend is slowing, continuing or accelerating. AirSAR will also provide reliable information on ice shelf thickness to measure the contribution of the glaciers to sea level. P0 is synthesized by Schwann cells, processed in the endoplasmic reticulum ER and enters the secretory pathway. Accumulation of P0S63 del in the ER triggers a persistent unfolded protein response.